Download Williams Obstetrics: 22nd Edition by F. Cunningham, Kenneth Leveno, Steven Bloom, John Hauth, PDF

By F. Cunningham, Kenneth Leveno, Steven Bloom, John Hauth, Larry Gilstrap, Katharine Wenstrom

This handbook presents clinicians with a pocket-sized distillation of key proof and diagnostic and therapy protocols from the authoritative "Williams Obstetrics, twenty first Edition". This moveable reference, contains chosen tables and illustrations from the most textual content, plus up to date references and remedy guidance.

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Extra info for Williams Obstetrics: 22nd Edition

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Ces lésions constituent une entité très particulière appelée « endothéliose glomérulaire », qui est retrouvée chez 80 % des femmes prééclamptiques. De récents travaux ont montré que le VEGF joue un rôle important dans la physiopathologie de la dysfonction endothéliale au cours de la PE [57,64–67]. Le VEGF et le PlGF 30 V. Tsatsaris, T. Fournier, N. Winer sont des facteurs de croissance impliqués dans les processus d’angiogenèse et de vasculogenèse. Ce sont des facteurs indispensables à la survie des cellules endothéliales.

Ces modifications sont responsables d’une relaxation des cellules musculaires lisses et d’une diminution des résistances vasculaires périphériques et de la pression artérielle. En cas de PE, les cytokines produites par le placenta et déversées dans la circulation maternelle inhibent les facteurs myorelaxants précédemment décrits et augmentent la production de facteurs responsables d’une contraction des cellules musculaires lisses comme les endothélines (ET-1) et le thromboxane (TXA2). De plus, ces cytokines libérées par le placenta sont capables d’activer le système rénine-angiotensine induisant une production d’angiotensine II.

Trophoblast deportation in pre-eclamptic pregnancy. Br J Obstet Gynaecol 1991 ; 98 : 973–979. W. The effect of placental syncytiotrophoblast microvillous membranes from normal and pre-eclamptic women on the growth of endothelial cells in vitro. Br J Obstet Gynaecol 1993 ; 100 : 943–944. , Holzgreve W. et al. Elevation of both maternal and fetal extracellular circulating deoxyribonucleic acid concentrations in the plasma of pregnant women with preeclampsia. Am J Obstet Gynecol 2001 ; 184 : 414–419.

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