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By Cameron McNeish,Chris Townsend

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Extra info for The Great Outdoors, jan.2010

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Similar questions have been asked concerning generation of ganglion cells, amacrine cells, and bipolar cells. The overall goal is to then integrate these findings to understand how intrinsic properties of progenitors contribute to the production of each cell type. Do the original, totipotent retinal progenitors change during development? If so, how? Do these changes indicate a gain or loss of competence to respond to the environmental cues defined by the studies of each cell type? Do they indicate loss of potency to make certain cell types?

On the one hand, physiological mapping of L- or M-cone inputs supports the labeled line model of cone type-specific connections to both the center and the surround of the midget cell receptive field. The “private line” from a single cone to a single midget ganglion cell can account for a pure cone center response. On the other hand, there is as yet no identified anatomical basis for a cone-typespecific center in the peripheral retina, where the larger receptive fields of midget ganglion cells receive convergent, additive input from both L- and M-cones.

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