By Kurt Benirschke, Graham J. Burton, Rebecca N Baergen
Pathology of the Human Placenta is still the main accomplished and authoritative textual content within the box. It offers vast info at the general placenta, encompassing body structure, metabolism, and endocrinology, and covers the whole diversity of placental illnesses in nice aspect. extra chapters are dedicated to abortions, molar pregnancies, a number of pregnancies, and felony issues. This 6th variation of the booklet has been largely revised and increased to mirror the latest growth within the box, and a new bankruptcy has been further on man made reproductive expertise. a few 800 illustrations are incorporated, lots of them in colour. The targeted index has been extra more advantageous and tables up-to-date. Pathology of the Human Placenta should be of huge price to pathologists and obstetrician-gynecologists alike.
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Additional resources for Pathology of the Human Placenta
These are highly active throughout the first 2 months of pregnancy, forming round to star-shaped lumina lined by columnar epithelium. During much of the first trimester, the decidua basalis beneath the placenta has a thickness of 5–6 mm. The gland secretions are discharged into the intervillous space through openings in the developing basal plate (see Sect. 5). The glands are surrounded by endometrial stroma or decidualized endometrial stromal cells, extravillous trophoblast cells, and maternal uterine natural killer cells.
During early pregnancy, they form a complete and usually multilayered stratum; in later pregnancy, this layer becomes rarefied. Some of the cells deeply invade the fibrinoid (see Chap. 11: Chorionic Plate) (see Sect. 5). Attached to or embedded into the fibrinoid, one finds numerous stem villi, representing the first branches of stem villi branching off from the chorionic plate nearby (see upper third of Fig. 2a). The chorionic plate represents the cover of the intervillous space, which lies directly below.
Typically, they bulge against the trophoblastic surface and transform this into extremely thin vasculosyncytial membranes that are devoid of nuclei. The terminal villi, together with mature intermediate villi, represent the main exchange area of the third trimester placenta. Mature intermediate villi with slender capillaries and terminal villi with dilated sinusoids are easily discernible in placentas following early cord clamping and immediate fixation. Placentas that were fixed late after delivery and have lost larger amounts of fetal blood show the collapse of sinusoids so that the terminal villi can no longer be discriminated from mature intermediate villi, which have slender capillaries.