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Content:
Chapter 1 Chairman's creation (pages 1–2):
Chapter 2 The position of the Drug?Metabolizing Enzymes (pages 5–24): James W. Bridges
Chapter three The impact of Inducers on Drug?Metabolizing Enzyme job and on Formation of Reactive Drug Metabolites within the Liver (pages 25–42): Sten Orrenius, Hjordis Thor and Bengt Jernstrom
Chapter four results of Inducers and Inhibitors on Drug?Metabolizing Enzymes and on Drug Toxicity in Extrahepatic Tissues (pages 43–66): Michael R. Boyd
Chapter five Induction of Enzymes fascinated by DNA fix and Mutagenesis (pages 67–81): B. A. Bridges
Chapter 6 Induction of Drug?Metabolizing Enzymes via Polycyclic fragrant Hydrocarbons: Mechanisms, and a few Implications in Environmental wellbeing and fitness learn (pages 83–99): John R. Bend
Chapter 7 Induction of Drug?Metabolizing Enzymes by way of Phenobarbitone: Structural and Biochemical points (pages 101–118): Urs A. Meyer, Peter J. Meier, Hans Hirsiger, Urs Giger and Felix R. Althaus
Chapter eight Substrate?Dependent Irreversible Inactivation of Cytochrome P?450: Conversion of Its Haem Moiety into changed Porphyrins (pages 119–139): Francesco De Matteis, Anthony H. Gibbs, Lavinia Cantoni and Jean Francis
Chapter nine legislation of Human Drug Metabolism by means of nutritional components (pages 147–167): A.H. Conney, M.K. Buening, E.J. Pantuck, C.B. Pantuck, J.G. Fortner, K.E. Anderson and A. Kappas
Chapter 10 Infiuence of international Compounds on Formation and Disposition of Reactive Metabolites (pages 169–189): F. Oesch
Chapter eleven Pharmacokinetic components Governing the Steady?State Concentrations of international chemical substances and Their Metabolites (pages 191–217): James R. Gillette
Chapter 12 Toxicological Implications of Polymorphic Drug Metabolism (pages 219–244): J.C. Ritchie, T.P. Sloan, J.R. Idle and R.L. Smith
Chapter thirteen Immunologically Mediated Toxicity (pages 245–259): H.E. Amos
Chapter 14 Toxicological value of Liver Hypertrophy Produced via Inducers of Drug?Metabolizing Enzymes (pages 261–274): Emmanuel Farber
Chapter 15 The impact of meals and Inducers on Mechanisms of Toxicity in people and Animals (pages 275–288): Andre E.M. McLean, David J. Wltts and Denise Tame
Chapter sixteen impression of Environmental chemical compounds on Drug treatment in people: reports with Contraceptive Steroids (pages 289–306): A.M. Breckenridge, D.J. again, Karen go, Francesca Crawford, M. MacIver, M. L'E Orme, P.H. Rowe and Eileen Smith
Chapter 17 nutrition D Metabolism in sufferers handled with Phenytoin and Phenobarbitone (pages 315–330): J.O. Hunter and M. Davie
Chapter 18 Chemical affliction in people: difficulties in Comparative Toxicology (pages 331–347): Irving J. Selikoff
Chapter 19 Implications for destiny reviews in people (pages 349–358): John Higginson

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Additional resources for Ciba Foundation Symposium 76 - Environmental Chemicals, Enzyme Function and Human Disease

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J Cell Biol 26:725-733 Orrenius S, Ernster L 1964 Phenobarbital-induced synthesis of the oxidative demethylating enzymes of rat liver microsomes. Biochem Biophys Res Commun 16:60-65 Orrenius S, Anderson B, Jernstrom B, Moldeus P 1979 Isolated hepatocytes as an experimental tool in the study of drug conjugation reactions. In: Aitio A (ed) Conjugation reactions in drug biotransformation. Elsevier/North-Holland Biomedical Press, Amsterdam, p 273-302 Recknagel RO, Glende EA 1973 Carbon tetrachloride hepatotoxicity: an example of lethal cleavage.

I . Role of drug metabolism. J Pharmacol Exp Ther 187:185-194 Potter WZ, Thorgeirsson SS, Jollow DJ, Mitchell JR 1974 Acetaminophen-induced hepatic necrosis. V . Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters. Pharmacology 12: 129-143 Shu H , Talcott RE, Rice SA, Wei ET 1979 Lipid peroxidation and paraquat toxicity. Biochem Pharmacol 28:327-33 1 Smith LL, Rose MS, Wyatt I 1979 The pathology and biochemistry of paraquat. In: Oxygen free radicals and tissue damage.

Metabolic activation of carbon tetrachloride proceeds by formation of the free radical CCl3 (Recknagel & Glende 1973), while the highly electrophilic species bromobenzene-3 ,Cepoxide is probably the primary cytotoxic metabolite of bromobenzene (Jollow et a1 1974, Jollow & Smith 1977). The available evidence indicates that carbon tetrachloride exerts its hepatotoxic effect by initiating lipid peroxidation, whereas the cytotoxic mechanism of bromobenzene depends on alkylation of nucleophilic groups in the tissue.

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