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By Eugene C. Toy

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2) one can see that the incidence of IVH decreases as gestational age and birth weight increase and that the incidence of major ultrasound abnormalities (IVH gr III and IV) and cysts (including periventricular leukomalacia) is approximately 5% in babies above 1250 g or at or above 30 weeks. Therefore it seems prudent to recommend delivery at a minimum of 30 weeks' gestation to allow preterm infants to be born with a low risk of major handicap and to permit initiation of maternal antineoplastic chemotherapy or radiation.

N. Kelly 19. The Scottish Low Birthweight Study Group: I. Survival, growth, neuromotor and sensory impairment. Arch Dis Child 1992; 67: 675-81. 20. ): Maternal-Fetal Medicine. 1994 p. 1115, WB Saunders Co. Philadelphia, London, Toronto, Montreal, Sydney, Tokyo. 21. ): Williams Obstetrics 1993, p. 1274, Appleton & Lange, Norwalk, Connecticut. Changes in drug disposition during pregnancy and their clinical implications G. KOREN For obvious reasons, almost none of the research projects involved in understanding pregnancy-induced changes in drug disposition has been conducted in women with cancer or in other women receiving cancer chemotherapy for adverse indications.

Conflict between fetal beneficence-based obligations of the mother and fetal beneficence-based obligations of the physician Usually the mother and her physicians are in agreement as to the best interest of the fetus. However, the mother and the physician may differ on the need for specific treatment or investigation. This difference is not necessarily dependent on information given to the mother but may be due to different perception or acceptance of risks. For example, the physician may be reluctant to perform invasive tests (such as amniocentesis looking for the chromosomal effects of chemotherapy in the first trimester) if he believes that the risk is very low, while for the mother any such risk may be unacceptable.

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