By Marian H Jackson; Linda F Westbrook
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Extra info for Borderline personality disorder : new research
American Psychologist, 63, 62-63. , Sanderson, C. , Jr. (2002). A description of the DSM-IV personality disorders with the five-factor model of personality. Costa & T. A. , pp. 89-99). Washington: American Psychological Association. A. M. (1991) Epidemiology of borderline personality-disorder. , Ahnemark, E. et al. (2006) Tryptophan hydroxylase-1 gene variants associate with a group of suicidal borderline women. L. G. (1987) The Diagnostic Interview for Personality-Disorders - Interrater and test-retest reliability.
The authors conclude that 5-HTT may play a role in the etiology of BPD. Pascual et al. (2008) however, were not able to replicate this finding in 86 BPD patients and 100 control subjects. The authors give the clinical heterogeneity of BPD patients as a possible cause of the differential outcome and suggest that future association studies should focus on genetically homogenous subgroups of BPD patients. Besides serotonergic dysfunction, there is some evidence that dopamine (DA) dysfunction may be associated with BPD.
Spouses of twins can be included to study marital resemblance which can be due to social homogamy, marital interaction or phenotypic assortment (Heath & Eaves 1985). Social homogamy refers to the tendency of spouses to have similar social backgrounds. Marital interaction means that spouses living together experience mutual influences which makes them resemble each other, or active influences of one spouse on the other (Penrose 1944). Phenotypic assortment refers to the tendency of individuals to select their partner based on the partner’s phenotype.