By C.C. Reddy (Eds.)
The second one of 2 volumes featuring present study into oxidation platforms, this booklet is meant for biochemists, toxicologists, and pharmacologists. themes mentioned comprise oxidation mechanisms in carcinogenesis, lipid peroxidation and different non-enzymatic reactions of oxygen
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Additional resources for Biological Oxidation Systems. Volume 2
R. (1988) Chem. Res. Toxicol. 1,356-363 17. A. (1988) Chem Biol. Interacn. 65,261-273 18. , Ross, D.. T. (1987) Chem-Biol. Interacn. 63,47-62 19. , and Wei, M. (1982) /. Clin. Invest. 70, 598-607 20. I. (1983) Nature 301,715-716 21. M. (1983) /. Clin. Invest. 72, 441-453 22. L. (1984) /. Biol. Chem 259,10404-10412 23. Weiss, SJ. (1986)Adv. in Free Radical Biology and Medicine 2,91-106 24. , and Regiane, D. (1986) Science 234,200-203 25. C. (1969) Klin. Wsch. 23,1286-1287 26. , and Wahlqvist, L.
T. (1987) Chem-Biol. Interacn. 63,47-62 19. , and Wei, M. (1982) /. Clin. Invest. 70, 598-607 20. I. (1983) Nature 301,715-716 21. M. (1983) /. Clin. Invest. 72, 441-453 22. L. (1984) /. Biol. Chem 259,10404-10412 23. Weiss, SJ. (1986)Adv. in Free Radical Biology and Medicine 2,91-106 24. , and Regiane, D. (1986) Science 234,200-203 25. C. (1969) Klin. Wsch. 23,1286-1287 26. , and Wahlqvist, L. (1977) Acta Path. Microhiol Scand. Sect A. 85, 768-774 27. A. (1983) Br. J. Urol. 55,220-224 28. C. (1981) DrugMetab.
Endogenous formation of N-nitroso compounds in the human as well as in animal models from nitrite and amines or amides have been documented (10, 11). Ascorbic acid was the first naturally occurring substance found to effectively block the formation of Nnitroso compounds (9, 12, 13). Animals administered with appropri ate precursor compounds form nitroso carcinogens and subsequently develop tumors. Under these conditions, administration of ascorbic acid in the diet to the animals will prevent the formation of nitroso compounds and occurrance of tumors.